IGF1-LR3, Insulin-like growth factor is a highly anabolic hormone that is released in the liver as well as in the peripheral tissues in response to the growth hormone so that a new muscle could be built. The main work of IGF-1 is to build new muscle tissues by promoting nitrogen retention and protein synthesis. It differs from original IGF-1 in that it possesses an arginine instead of a glutamic acid and also has an additional 13 amino acids. As a result, it is approximately three times more potent than IGF-1 and possesses a significantly longer half-life of about 20–30 hours (comparative to IGF-1’s half-life of about 12–15 hours).
IGF-1 is closely related to a second protein called “IGF-2“. IGF-2 also binds the IGF-1 receptor. However, IGF-2 alone binds a receptor called the “IGF-2 receptor” (also called the mannose-6 phosphate receptor). The insulin-like growth factor-II receptor (IGF2R) lacks signal transduction capacity, and its main role is to act as a sink for IGF-2 and make less IGF-2 available for binding with IGF-1R. As the name “insulin-like growth factor 1” implies, IGF-1 is structurally related to insulin, and is even capable of binding the insulin receptor, albeit at lower affinity than insulin. IGF-1 LR3 is the primary protein involved in responses of cells to growth hormone (GH): that is, IGF-I is produced in response to GH and then induces cellular activities. One such example is muscle growth or hyperplasia. This compound also makes the human body more sensitive to insulin. It is the most potent growth factor found in the human body. IGF-1 causes muscle cell hyperplasia, which is an actual splitting and forming of new muscle cells. The most effective form of IGF-1 is considered to be IGF-1 LR3. This formula has been chemically altered to avoid binding to proteins in the human body, and to increase the half life, approximately 20-30 hours.
- Enhance muscle mass and strength
- Decreases inflammation and autoimmunity
- Reduces muscle wasting
- Improve gut health
- Boost collagen production
- Builds muscle
- Help balance blood insulin levels
- Supports weight loss